Requirement for Interaction of PI3-Kinase p110a

with RAS in Lung Tumor Maintenance

Esther Castellano,1,7 Clare Sheridan,1,7 May Zaw Thin,2 Emma Nye,3 Bradley Spencer-Dene,3 Markus E. Diefenbacher,4
Christopher Moore,1 Madhu S. Kumar,1 Miguel M. Murillo,1,6 Eva Gro¨ nroos,5 Francois Lassailly,2 Gordon Stamp,3
and Julian Downward1,6,*
1Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
2In Vivo Imaging Facility, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
3Experimental Histopathology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
4Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
5TranslationalCancerTherapeutics Laboratory,Cancer ResearchUKLondonResearch Institute, 44 Lincoln’s Inn Fields, LondonWC2A3LY,UK
6Lung Cancer Group, Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
7These authors contributed equally to this work
*Correspondence: julian.downward@cancer.org.uk

Cancer Cell 24, 617?630, November 11, 2013 ª2013 The Authors