Cancer Cell

Selective Requirement of PI3K_PDK1 Signaling

for Kras Oncogene-Driven Pancreatic Cell

Plasticity and Cancer

Stefan Eser,1,9 Nina Reiff,1,9 Marlena Messer,1,9 Barbara Seidler,1 Kathleen Gottschalk,1 Melanie Dobler,1 Maren Hieber,1
Andreas Arbeiter,1 Sabine Klein,1 Bo Kong,2 Christoph W. Michalski,2 Anna Melissa Schlitter,3 Irene Esposito,3,8
Alexander J. Kind,4 Lena Rad,5 Angelika E. Schnieke,4 Manuela Baccarini,6 Dario R. Alessi,7 Roland Rad,1,5,8
Roland M. Schmid,1,8 Gu¨ nter Schneider,1 and Dieter Saur1,8,*
1Department of Internal Medicine 2
2Department of Surgery
3Institute of Pathology
4Livestock Biotechnology
Technische Universita¨t Mu¨ nchen, Ismaningerstr. 22, 81675 Mu¨ nchen, Germany
5Wellcome Trust Sanger Institute, Genome Campus, Hinxton-Cambridge CB10 1SA, UK
6Department of Microbiology and Immunobiology, University of Vienna, Max F. Perutz Laboratories, Doktor-Bohr-Gasse 9,
1030 Vienna, Austria
7MRC Protein Phosphorylation Unit, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
8German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
9These authors contributed equally to this work
*Correspondence: dieter.saur@lrz.tum.de
http://dx.doi.org/10.1016/j.ccr.2013.01.023